The Efficacy and Safety of a Low-Fluence 1064 nm Picosecond ND-YAG Laser Compared with Those of a Low-Fluence Photoacoustic Therapy Pulsed (PTP) Mode 1064 nm Q-Switched ND-YAG Laser for Treatment of Melasma: A Prospective Split-Face Study

Melasma is a challenging pigmentation disorder to treat, and although low-fluence 1064 nm picosecond ND-YAG lasers have shown potential for treating benign pigmented disorders, data on the use of this laser melasma treatment are currently insufficient. In prospective split-face study, twenty-four patients with face were enrolled randomly assigned receive one side either or PTP mode Q-switched laser. Laser was performed 5 times at intervals 2 weeks, evaluation conducted before each months after completion treatments. Clinical pictures using standardized, digital photographic system dermoscopy taken day visit. The modified area severity index (mMASI), melanin (MI), dermoscopic scores pigmentary vascular elements in melasma, pain during treatment, patient satisfaction score recorded. Twenty-one participants completed from week both groups, significant decrease mMASI MI confirmed. Although no statistically difference observed, greater group than group. showed improvement pseudoreticular network globular pattern features between 0 16, while No observed two groups terms Notably, adverse events conclusion, our study demonstrated that as effective safe